Down syndrome also known as trisomy 21, is a genetic disorder which occurs in approximately 1 in 700 live births globally, making it one of the most common genetic conditions. It is usually associated with developmental delays, characteristic physical features and mild to moderate intellectual disability. Early intervention and special education can greatly enhance their cognitive development Loxandra and Alexandros are a couple of artists from the “En Dynamei” group, a collective of young disabled and non-disabled artists. Loxandra became the first actress to play in the ancient theater of Epidaurus with the performance “Troades” of the State Theater of Northern Greece as well as in the performance of the National Theater “Fuente Ovehuna” With Alexandros, they have participated together in an episode of a well-known television series.